Which enzyme is induced by smoking, increasing the metabolism of some antipsychotics?

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Study for the HESI Schizophrenia Case Study Test. Prepare with flashcards and multiple choice questions, each question provides hints and explanations. Get ready for your exam!

Multiple Choice

Which enzyme is induced by smoking, increasing the metabolism of some antipsychotics?

Explanation:
Smoking induces the enzyme CYP1A2, driven by components in tobacco smoke that activate this specific pathway. Antipsychotics such as clozapine and olanzapine are metabolized primarily by CYP1A2, so when someone smokes, their body speeds up the breakdown of these drugs. The result is lower drug levels in the blood and a potential need for dose adjustments to maintain efficacy. Other enzymes listed don’t get as strongly induced by smoking, so they’re less relevant to the change in antipsychotic metabolism seen with smoking.

Smoking induces the enzyme CYP1A2, driven by components in tobacco smoke that activate this specific pathway. Antipsychotics such as clozapine and olanzapine are metabolized primarily by CYP1A2, so when someone smokes, their body speeds up the breakdown of these drugs. The result is lower drug levels in the blood and a potential need for dose adjustments to maintain efficacy. Other enzymes listed don’t get as strongly induced by smoking, so they’re less relevant to the change in antipsychotic metabolism seen with smoking.

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